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The practical implication is clear: reconstitute only what you will use within a reasonable timeframe

In some embodiments, the ratio of a thermoreversible poloxamer to a thickening agent in a formulation that has a pH as described herein is about 40:1, about 35:1, about 30:1, about 25:1, about 20:1, about 15:1, about 10:1, or about 5:1

The theoretical rationale is strong, supported by decades of immunology research demonstrating its Th1/Treg-promoting effects and the well-established Th2 dominance of eczema